Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX.
نویسندگان
چکیده
Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 80 شماره
صفحات -
تاریخ انتشار 2012